Oxygen Therapy: Bryan Johnson claims he has the biology of a 10-year-old—thanks to oxygen therapy. Can science really turn back time? |

Imagine waking up with the energy levels, organ functions, and biological markers of a 10-year-old at 46. That’s exactly what tech entrepreneur and self-proclaimed biohacker Bryan Johnson claims he has achieved, and he credits it to a radical experiment: 90 days of intense oxygen therapy.Johnson, known for spending millions annually on anti-aging regimens under his Blueprint project, recently announced that this latest venture has helped him “reverse” aspects of his biological age to that of a pre-teen. His claims, though bold, are grounded in an evolving field of science where longevity research is beginning to intersect with what was once considered science fiction.

What is oxygen therapy?

The treatment at the center of Johnson’s latest experiment is hyperbaric oxygen therapy (HBOT). While oxygen therapy in general refers to the medical use of supplemental oxygen, HBOT involves breathing pure oxygen in a pressurized chamber. These chambers are typically pressurized at two to three times normal atmospheric levels, enabling oxygen to dissolve more effectively into the bloodstream and reach tissues that may be oxygen-starved.This isn’t a new practice. HBOT has been FDA-approved for a range of medical conditions, including carbon monoxide poisoning, gangrene, non-healing wounds, and decompression sickness (common among divers). But over the last few years, HBOT has gained attention for its potential anti-aging and regenerative benefits.

How does HBOT work on the body?

Under normal conditions, oxygen is carried mostly by red blood cells. But when the body is exposed to high-pressure pure oxygen, more oxygen dissolves directly into the blood plasma. This super-oxygenated blood can then travel deeper into body tissues, promoting healing and rejuvenation at the cellular level.Some of the key reported benefits of HBOT include:

• Increased production of stem cells, which help regenerate damaged tissues
• Reduced inflammation across various organs
• Improved mitochondrial function, which boosts cellular energy
• Enhanced cognitive performance
• Potential telomere extension – telomeres are protective caps on DNA that shorten with age

A 2020 study conducted in Israel found that HBOT could not only increase the length of telomeres (often considered a marker of youthfulness) but also reduce senescent cells, which are old, malfunctioning cells that contribute to aging and disease.

Bryan Johnson’s results: Hype or hope?

According to Johnson, after 90 days of HBOT combined with his usual strict regimen of exercise, plant-based diets, sleep optimization, and regular medical testing, he experienced:

• Improvements in skin health
• Reduction in biological markers of aging
• Enhanced lung capacity and cardiovascular performance
• Better cognitive function and sleep quality

He claims that his overall biological profile, assessed using various biomarkers, now resembles that of a 10-year-old. It’s important to note, however, that biological age can be calculated differently depending on the metrics used, and it’s not a universally agreed-upon standard.

Is it safe and effective for everyone?

While Johnson’s transformation has captured the public’s imagination, medical experts urge caution. HBOT, though promising, is not without risks. Prolonged exposure can lead to oxygen toxicity, barotrauma (injury caused by pressure), and even vision changes.Moreover, the accessibility of such treatments remains limited. A full course of HBOT can cost thousands of dollars, and the kind of monitoring and medical supervision Johnson undergoes is far from standard.Dr. Shai Efrati, a pioneer in HBOT research, argues that with the right protocols and patient selection, HBOT could one day be used more broadly to slow biological aging, but more peer-reviewed studies are needed before it can be widely recommended.

A glimpse into the future?

Bryan Johnson’s experiment opens up exciting, if controversial, possibilities in the field of anti-aging and longevity science. It challenges traditional views of aging as a linear, irreversible process and suggests that, with the right tools, we might not only delay aging but potentially rewind certain biological clocks.Still, it’s essential to separate anecdotal success stories from scientific consensus. As fascinating as Johnson’s story is, it should serve as a launchpad for deeper inquiry, not a universal prescription.While the idea of having the biology of a 10-year-old at midlife sounds like a dream, the reality is far more nuanced. Oxygen therapy, particularly HBOT, holds promise, but it’s not a miracle solution, at least not yet. What Bryan Johnson’s journey does offer, however, is a compelling glimpse into the future of how we might age and perhaps, how we might not.



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